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Fraser Trevor Fraser Trevor Author
Title: Drugs such as cocaine and amphetamine produce their effects by changing the flow of neurotransmitters.
Author: Fraser Trevor
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 These drugs are defined as indirect acting because they depend on the activity of neurons. In contrast, some drugs bypass neurotransmitter...
 These drugs are defined as indirect acting because they depend on the activity of neurons. In contrast, some drugs bypass neurotransmitters altogether and act directly on receptors. Such drugs are direct acting.
Use of these two types of drugs can lead to very different results in treating the same disease. As mentioned earlier, people with Parkinson's disease lose neurons that contain dopamine. To compensate for this loss, the body produces more dopamine receptors on other neurons. Indirect agonists are not very effective in treating the disease since they depend on the presence of dopamine neurons. In contrast, direct agonists are more effective because they stimulate dopamine receptors even when dopamine neurons are missing.
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