Dysfunction of serotoninergic transmission could predispose to excessive alcohol consumption and dependence.

Drug and Alcohol Dependence (journal) (Photo credit: Wikipedia)

The functional polymorphism of the serotonin

transporter gene (5-HTTLPR) has been associated with

different disorders, including alcoholism. Considering the

likelihood of heterogeneity in the “alcohol dependence”

phenotype, 5-HTTLPR may be more specifically implicated in subsamples of patients or in related traits of

alcoholism, such as impulsivity.

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